Research Activities

Research topics

ICBH is currently focusing in 3 following topics:

  • metabolické changes in patients with end-stage renal disease
  • risk factors of cardiovascular diseases
  • biomarkers of organ damage, especially during oncologic treatment (with emphasis to myocardium and kidney damage), during sports activities and in patients with kidney diseases

We have been participating on solving folloving research projects:

  • projects belonging to the Charles University Research Fund (project number P36)
  • Ministry of Health, Czech Republic - conceptual development of research organization (Faculty Hospital in Pilsen - FNPl, 00669806)
  • projects in cooperation with Biomedical Center of Medical Faculty in Pilsen, Charles University in Prague
  • research project CZ.02.1.01/0.0/0.0/16_019/0000787 “Fighting INfectious Diseases“ (FIND)

A short notice about our research history can be found in the chapter about our institute history.

We are educating postgraduate students of biomedicine (PDSB) (pdsb.avcr.cz), study program biochemistry and pathobiochemistry; our institute educates posgraduate students since 2001/02.

The most important scientific publications

Monography

  • Rajdl D., Racek J. et al. (2016). Clinical Biochemistry. Karolinum Press, ISBN 978-80-246-3497-5, free download here
  • Racek J.: Oxidační stres a možnosti jeho ovlivnění (Oxidative Stress and Possibilities of Influencing It). Galén, Praha, 2003, 92 s. (ISBN 80-7262-231-5)
  • Racek J.: Cell-Based Biosensors. Technomic Publishing Co., Inc., Lancester, Pensylavania, USA, 1994, ISBN 1-56676-190-5
  • Racek J. et al.: Klinická biochemie (Clinical Biochemistry). Galén, Prague, 2006, ISBN 80-7262-324-9
  • Racek J. et al.: Klinická biochemie (Clinical Biochemistry). 2nd Edition, Galén and Karolinum, Prague, 1999, ISBN 80-7262-023-1 (Galén), 80-7184-971-5 (Karolinum) 
  • Racek J., Rajdl D. et al. Klinická biochemie (Clinical Biochemistry. 3rd Edition, Galén, Prague, 2021, ISBN 978-80-7492-545-0

Chapters in monography

  • Teplan V., Racek J. Asymmetric Dimethylarginine. In: Niwa, T. (Ed.): Uremic Toxins, Wiley, 2012, ISBN 978-1-118-13513-6
  • Cibulka R., Racek J. (2011). Metabolic Complications of Chronic Kidney Failure and Hemodialysis, Special Problems in Hemodialysis Patients, Maria Goretti Penido (Ed.), ISBN: 978-953-307-396-5, InTech, Available from: http://www.intechopen.com/articles/show/title/metabolic-complications-of-chronic-kidney-failure-and-hemodialysis
  • Racek J.: Vnitřní prostředí. In: Navrátil L. et al.: Vnitřní lékařství pro nelékařské zdravotnické obory. Grada Publishing, Prague, 2008, p. 151-176, ISBN 978-80-247-2319-8
  • Racek J.: Vliv střídmého pití světlého ležáku českého typu na rizikové faktory aterosklerózy u mužů středního věku. In: Emmerová et al.: Pivo a zdraví. NAVA, Pilsen, 2007, p. 35-40 (ISBN 978-80-7211-253-1)
  • Varvařovská R., Štětina R., Sýkora J., Rušavý Z., Racek J., Lacigová S., Siala K.: Impact of oxidative stress on diabetes mellitus and inflammatory bowel diseases. In:
    a) Panglossi, H. V. (ed.): Frontiers in Antioxidants Research, p. 133-200. Nova Science Publishers, Inc., 2006, ISBN 1-60021-273-5
    b) Panglossi, H. V. (ed.): Leading Edge Antioxidants Research, p. 179-245. Nova Science Publishers, Inc., 2006, ISBN 1-60021-274-3
  • Racek J.: Laboratorní vyšetření v ortopedii. In: Koudela, K. et al.: Ortopedie. Karolinum, Prague, 2004, p. 53-60, ISBN 80-246-0654-2
  • Racek J.: Biochemie kyslíku. In: Hájek M. et al.: Hyperbarická medicína. Mladá fronta, Edice Aeskulap, Prague, 2017, p. 40-53, ISBN 978-80-204-4235-2
  • Racek J.: Vnitřní prostředí. In: Navrátil L. et al.: Vnitřní lékařství pro nelékařské zdravotnické obory. Grada Publishing, Praha, 2nd edition, 2017, p. 343-369, ISBN 978-80-247-2319-8

The most important original articles (last 5 years)

  • Hromádka M., Rajdl D., Trefil L., Racek J., Rokyta R. Diagnostic sensitivity of high-sensitivity troponin T for acute myocardial infarction in patients with chest pain. Cor Vasa, 2012, 54: e227-e231 (IF 0,13)
  • Jehlicka P.Huml M.Rajdl D., Mockova A., Matas M., Dort J., Masopustova A. How to interpret elevated plasmatic level of high-sensitive troponin T in newborns and infants? Physiol Res, 2013, 67(2): 191-195 (IF 1,487)
  • Vokurka S., Svoboda T., Rajdl D., Sedlackova T., Racek J., Koza V., Trefil L. Serum citrulline levels as a marker of enterocyte function in patients after allogeneic hematopoietic stem cells transplantation – a pilot study. Med Sci Monit, 2013, 19: 81-85 (IF 1,358)
  • Sedlackova T., Racek J., Rajdl D., Kielberger L., Eiselt J., Malanova L., Babuska V. Relationship between hepcidin and ferritin in haemodilysed patients. Wien. Klin. Wschr., 125(15), 2013: 448-452 (IF 0,813)
  • Racek J., Sindberg C.D., Moesgsard S., Mainz J., Fábry J., Muller L., Rácová K. Effect of chromium-enriched yeast on fasting plasma glucose, glycated haemoglobin and serum lipid levels in patients with type 2 diabetes mellitus treated with insulin. Biol Trace Element Res, 2013, 155(1): 1-4 (IF 1,307)
  • Eiselt J., Rajdl D., Racek J., Vostrý M., Rulcová K., Wirth J. Asymmetric dimethylarginine and progression of chronic kidney disease – a one-year follow-up study. Kidney Blood Press Res, 2014, 39(6): 50-57 (IF 1,820)
  • Broz P., Rajdl D., Racek J., Petr T. Vitek L. Two case reports of extremely increased glycorrhachia in normoglycemic patients. Ann Clin Biochem, 2015, 51(1): 161-164 (IF 1,922)
  • Rajdl D., Racek J., Trefil L., Stehlík P., Dobrá J., Babuška V. Effect of folic acid, betaine, vitamin B6, and vitamin B12 on dimethylglycine levels in middle-aged men drinking white wine. Nutrients, 2016, 8, 34; doi:10.3390/nu8010034 (IF 3,270)
  • Šišková K., Dubničková M., Pašková L., Rajdl D., Ďuračková Z., Muchová J. Pauliková I., Racek J. Betaine increases the butyrylcholinesterase activity in rat plasma. Physiol Res, 2016, 65(1): 101-108 (IF 1,293)
    Eiselt J., Kielberger L., Rajdl D., Racek J., Pazdiora P., Malánová L. Previous vaccination and age are more important predictors of immune response to influenza vaccine then inflammation and iron status in dialysis patients. Kidney Blood Pres Res, 2016, 41: 139-147 (IF 2,123)
  • Broz P., Rajdl D., Racek J., Zenkova J., Petrikova V. Influence of pneumatic tube system transport on routinely assessed and spectrophotometric cerebrospinal fluid parameters. Clin Chem Lab Med, 2017, 55(1): 47-52 (IF 2,707)
  • Broz P., Rajdl D., Novak J., Hromadka M., Racek J., Trefil L., Zeman V. High sensitivity troponins after standardized two-hour treadmill run. J Med Biochem, 2018, 37(3): 364-372 (IF 1,378)
  • Racek J., Rajdl D., Jungová A. Severe hyperkalemia in a hemato-oncologic patient. Clin Chem, 2019, 65(2): 354-355 (IF 8,636)
  • Racek M., Racek J., Hupáková I. Scanning electron microscopy in analysis of urinary stones. Scand J Clin Lab Invest, 2019, 39(3): 208-217 (IF 1,471)
  • Nalos L.Sviglerova J.Rajdl D., Jedlička J., Dejmek J., Štengl M., Kuncová J. Norepinephrine turnover in the left ventricle of subtotally nephrectomized rats. Physiol Res, 2019, 68(Suppl. 3): ‏ S233-S242 (IF 1,655
  • Florová B., Rajdl D., Racek J., Matějka V.M., Trefil L. NGAL, albumin a cystatin C during cisplatin therapy. Physiol Res, 2020, 30(2): 307-317 (IF 1,701)
  • Jehlicka P.Rajdl D.Sladkova E., Sykorova A., Sykora J. Dynamic changes of high-sensitivity troponin T concentration during infancy: Clinical Implications. Physiol Res, 2021, 70(1): ‏ 27-32(IF 1,881)
  • Racek J., Rajdl D., Přenosilová P. Persistence of high serum digoxin concentration. Clin Chem, 2021 67(6): 915-916 (IF 7,292)

Prizes

  • are summarized in the chapter about education